Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis
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چکیده
منابع مشابه
Human recombinant endostatin Endostar attenuates hepatic sinusoidal endothelial cell capillarization in CCl4‑induced fibrosis in mice.
The aim of the present study was to detect the effect of the recombinant human endostatin Endostar on hepatic sinusoidal capillarization in CCl4‑induced murine models of liver fibrosis. The liver fibrosis model was induced in BALB/c mice using intraperitoneal injection of CCl4 for 6 weeks. Animals were divided into the following six treatment groups: Group 1, normal animals; group 2, CCl4‑induc...
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Purpose: To evaluate the histopathological changes of the cornea in rabbit corneas after accelerated collagen cross-linking. Methods: Right eyes of 7 adult New Zealand albino rabbits weighing 1.5 to 2.0 kg were studied. Right eyes of all animals were in the treatment group and left eyes were in the control group. The epithelium of all right eyes was removed and was crossed-linked with riboflavi...
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We have previously demonstrated that collagen type XV (ColXV) is a novel bone extracellular matrix (ECM) protein. It is well known that the complex mixture of multiple components present in ECM can help both to maintain stemness or to promote differentiation of stromal cells following change in qualitative characteristics or concentrations. We investigated the possible correlation between ColXV...
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Among the various consequence arising from lung injury, hepatic fibrosis is the most severe. Decreasing the effects of hepatic fibrosis remains one of the primary therapeutic challenges in hepatology. Dysfunction of hepatic sinusoidal endothelial cells is considered to be one of the initial events that occur in liver injury. Vascular endothelial growth factor signaling is involved in the progre...
متن کاملLiver X receptor α is essential for the capillarization of liver sinusoidal endothelial cells in liver injury.
Liver X receptors (LXRs) play essential roles in lipogenesis, anti-inflammatory action and hepatic stellate cells (HSCs) activation in the liver. However, the effects of LXRs on the capillarization of liver sinusoidal endothelial cells (LSECs) in liver fibrosis remain undetermined. Here, we demonstrated that LXRα plays an important role in LSECs capillarization in a manner that involved Hedgeho...
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ژورنال
عنوان ژورنال: International Journal of Clinical Oncology
سال: 2015
ISSN: 1341-9625,1437-7772
DOI: 10.1007/s10147-015-0888-2